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Medical Information:

Entacapone (in-TACK-a-pohn)is used in combination with levodopa/carbidopa to treat Parkinson's disease, sometimes referred to as shaking palsy. Some patients experience signs and symptoms of end-of-dose “wearing-off” effect despite taking levodopa/carbidopa.

Entacapone enhances the effect of levodopa/carbidopa. By improving muscle control, this medicine allows more normal movements of the body.

Comtan is used for Parkinson's disease. It is prescribed when doses of the combination drug levodopa/carbidopa (Sinemet) begin to wear off too soon. By extending the effect of each dose of Sinemet, it frees the patient from the stiffness and tremors of Parkinson's for a longer period of time.

Comtan works by inhibiting the effect of an enzyme that breaks down the levodopa in Sinemet. It has no effect on Parkinson's disease when used by itself.When used with levodopa and carbidopa, entacapone increases levels of levodopa (Dopar, Larodopa, Sinemet) in the body.

Entacapone is used with carbidopa and levodopa to treat patients with Parkinson's disease who experience the signs and symptoms of end-of-dose "wearing-off". Entacapone is used only in combination with carbidopa and levodopa. It has no effect if it is used on its own.

Treating Parkinson disease when used with levodopa/carbidopa.

Comtan is a catechol-o-methyltransferase (COMT) inhibitor. It works by increasing the levels of levodopa/carbidopa in the brain, thereby enhancing its effectiveness.