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Uprima® is a potent agonist of dopamine.
Specifically it acts upon D1 receptor sites, and this makes it different from the majority of ergot derived drugs for dopamine improvement, such as bromocriptine, which normally target D2 receptors.
Uprima® doesn’t act directly upon the penis like Viagra® or Befar®, but instead exerts its influence in the brain for arousal, pleasure, and orgasm.
Uprima® acts upon receptors in the hypothalamus and can enhance erection by increasing the signals from the brain to begin the process.
Specifically, Uprima® induces selective activation in the nucleus paraventricularis, leading to erectogenic signals.
It is this brain action that makes Uprima® a unique new approach to the treatment of erectyle disfunction. As Dr. Dula stated after being involved with a trial of 1472 patients using Uprima®; “From a urologist’s perspective, it is important to understand that this is an entirely novel agent and works totally different from Sildenafil (Viagra®). It is a centrally-acting agent. What’s more, apomorphine works fairly quickly, in 15-25 minutes.
The main side effect is nausea, but over time and repeated dosages it rapidly dissipates. We think that it is a safe and efficacious treatment for erectile dysfunction.
FDA Committee Recommends Uprima (Apomorphine) Sublingual Tablets For Erectile Dysfunction
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